Ongoing Epidemiological Studies


The Kristine Yaffe Lab investigates risk factors associated with cognitive decline and dementia among older adults in several large ongoing epidemiological studies. A brief description of current epidemiological studies under investigation can be found below:

The Coronary Artery Risk Development in Young Adults (CARDIA) Study

CARDIA is an observational cohort study of 5115 black and white adults. Participants were young adults between the ages of 18-30 years at enrollment in 1985-86. With a focus on early adult cardiovascular risk factors, CARDIA is sponsored by the National Heart, Lung and Blood Institute. An in depth description of CARDIA can be found ►HERE.

The Chronic Effects of Neurotrauma Consortium (CENC): Epidemiology Study

The CENC Epidemiology Study is a comprehensive database study evaluating the chronic effects of mild traumatic brain injury (mTBI) in Veterans over time. The goal of the study is to better understand the sequelae of clinical and cognitive outcomes of mTBI among Veterans in order to develop and advance methods to treat and rehabilitate chronic neurodegenerative disease and comorbid effects of mTBI. The CENC Epidemiology Study is supported by the Department of Defense. More information on the study can be found ►HERE.   

The Health, Aging, and Body Composition (HABC) Study

HABC is an ongoing longitudinal cohort study of 3075 community dwelling, black and white older adults who were aged 70-79 years at enrollment in 1997-98 and who were well-functioning at the start of the study. The goal of the Health ABC Study is to identify characteristics and comorbidities associated with physical and cognitive changes that occur with aging. HABC is funded by the National Institute on Aging. More detailed information on the Health ABC study can be found ►HERE.

The Study of Osteoporotic Fractures (SOF)

SOF is prospective multi-center study of over 10,000 older women. Participants were ≥ 65 years old at enrollment in 1986. While SOF’s original goal was to understand risk factors for osteoporotic fractures, the study has evolved over time and now focuses on predictors of successful aging. SOF is funded by the National Institute on Aging. More detailed information is available ►HERE.

The Osteoporotic Fractures in Men (MrOS) Study

The Osteoporotic Fractures in Men Study (MrOS) is a large multi-center observational study of 5,994 community-dwelling men designed to identify risk factors for osteoporosis in men.  Participants were ≥ 65 years old at enrollment in 2000-2002. the study is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Institute on Aging (NIA), the National Center for Research Resources (NCRR) and the NIH Roadmap for Medical Research. More detailed information is available ►HERE.

The Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT)

SMARRT is a randomized pilot study to test a personalized, pragmatic, multi-domain Alzheimer’s risk reduction intervention in a US integrated healthcare delivery system. Participants were 200 higher-risk older adults (age ≥ 70) who were randomly assigned to a two-year Alzheimer’s risk reduction intervention (SMARRT) or a Health Education control at enrollment. The goal of SMARRT is to provide information on preventing cognitive decline leading to Alzheimer’s disease in high-risk individuals. SMARRT is supported by the National Institute on Aging HERE.