Raquel Gardner, MD

Assoc Adjunct Professor
M_Neurology

Raquel Gardner, MD received her MD from Harvard University. She completed her internship in internal medicine and residency in neurology at UCSF and was a Behavioral Neurology Fellow at the UCSF Memory and Aging Center in 2012. Her research focuses on the cognitive and behavioral effects of traumatic brain injury (TBI) among older adults.

Publications: 

Alzheimer's pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome.

Alzheimer's research & therapy

Asken BM, Tanner JA, Gaynor LS, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, Fonseca C, Shankar R, Grant H, Smith K, Lago AL, Xu H, La Joie R, Cobigo Y, Rosen H, Perry DC, Rojas JC, Miller BL, Gardner RC, Wang KKW, Kramer JH, Rabinovici GD

Association between Insomnia and Mental Health and Neurocognitive Outcomes Following Traumatic Brain Injury.

Journal of neurotrauma

Wickwire E, Albrecht JS, Capaldi VF, Jain S, Gardner RC, Smith MT, Williams S, Collen J, Schnyer DM, Giacino J, Nelson LD, Mukherjee P, Sun X, Werner K, Mosti C, Markowitz AJ, Manley GT, Krystal AD

Prognostic Value of Frailty for Outcome Following Traumatic Brain Injury (TBI): A Systematic Review and Meta-Analysis.

Journal of neurotrauma

Roohollahi F, Molavi S, Mohammadi M, Mohamadi M, Mohammadi A, Kankam SB, Farahbakhsh F, Moarrefdezfouli A, Peters ME, Albrecht JS, Gardner RC, Rahimi-Movaghar V

Traumatic Brain Injury and Long-Term Risk of Stroke Among US Military Veterans.

Stroke

Schneider ALC, Peltz CB, Li Y, Bahorik A, Gardner RC, Yaffe K

Telehealth delivery of group-format cognitive rehabilitation to older veterans with TBI: a mixed-methods pilot study.

Applied neuropsychology. Adult

Kornblith E, Schweizer S, Abrams G, Gardner R, Barnes D, Yaffe K, Novakovic-Agopian T

Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study.

Neurotrauma reports

Yue JK, Kobeissy FH, Jain S, Sun X, Phelps RRL, Korley FK, Gardner RC, Ferguson AR, Huie JR, Schneider ALC, Yang Z, Xu H, Lynch CE, Deng H, Rabinowitz M, Vassar MJ, Taylor SR, Mukherjee P, Yuh EL, Markowitz AJ, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley GT, Wang KKW

Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist.

Neurology

Alcolea D, Beeri MS, Rojas JC, Gardner RC, Lle? A

Medical and Psychiatric Risk Factors for Dementia in Veterans with and without Traumatic Brain Injury (TBI): A Nationwide Cohort Study.

The journal of prevention of Alzheimer's disease

R.C. Gardner, D.E. Barnes, Y. Li, J. Boscardin, C. Peltz, K. Yaffe

Characteristics and Outcomes of Traumatic Brain Injury among Older Adults with and without Pre-injury Dementia: an Israel National Trauma Registry Study.

Alzheimer's & Dementia

Raquel C. Gardner, Irit Cohen-Manheim, Adi Givon, Irina Radomislensky, Moran Bodas, the Israel Trauma Group

Medical and Psychiatric Risk Factors for Dementia in Veterans with and without Traumatic Brain Injury (TBI): A Nationwide Cohort Study.

Alzheimer's & Dementia

Raquel C. Gardner, Deborah E Barnes, Amber L Bahorik, Yixia Li, Carrie Peltz, Kristine Yaffe

Effects of age and time since injury on traumatic brain injury blood biomarkers: a TRACK-TBI study.

Brain communications

Gardner RC, Puccio AM, Korley FK, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Puffer RC, Yuh EL, Yue JK, Sun X, Taylor SR, Mukherjee P, Jain S, Manley GT, TRACK-TBI Investigators

Feasibility and Utility of a Flexible Outcome Assessment Battery for Longitudinal Traumatic Brain Injury Research: A TRACK-TBI Study.

Journal of neurotrauma

Bodien YG, Barber J, Taylor SR, Boase K, Corrigan JD, Dikmen S, Gardner RC, Kramer JH, Levin H, Machamer J, McAllister T, Nelson LD, Ngwenya LB, Sherer M, Stein MB, Vassar M, Whyte J, Yue JK, Markowitz A, McCrea MA, Manley GT, Temkin N, Giacino JT

Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study.

The Lancet. Neurology

Korley FK, Jain S, Sun X, Puccio AM, Yue JK, Gardner RC, Wang KKW, Okonkwo DO, Yuh EL, Mukherjee P, Nelson LD, Taylor SR, Markowitz AJ, Diaz-Arrastia R, Manley GT, TRACK-TBI Study Investigators

Comparison Groups Matter in Traumatic Brain Injury Research: An Example with Dementia.

Journal of neurotrauma

Albrecht JS, Gardner RC, Wiebe D, Bahorik A, Xia F, Yaffe KC

Associations of Preexisting Vascular Risk Factors With Outcomes After Traumatic Brain Injury: A TRACK-TBI Study.

The Journal of head trauma rehabilitation

Schneider ALC, Barber J, Temkin N, Gardner RC, Manley G, Diaz-Arrastia R, Sandsmark D

Multimodal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinico-Pathological Case Series.

Journal of neurotrauma

Asken B, Tanner JA, VandeVrede L, Casaletto KB, Staffaroni AM, Mundada N, Fonseca C, Iaccarino L, La Joie R, Tsuei T, Mladinov M, Grant H, Shankar R, Wang KKW, Xu H, Cobigo Y, Rosen H, Gardner RC, Perry DC, Miller BL, Spina S, Seeley WW, Kramer J, Grinberg LT, Rabinovici G

Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology.

Neurology

Asken BM, Tanner JA, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Soleimani-Meigooni D, Rojas JC, Gardner RC, Miller BL, Grinberg LT, Boxer AL, Kramer JH, Rabinovici GD

Abstract 024: Traumatic Brain Injury And Long-term Risk Of Stroke Among U.S. Military Veterans.

Circulation

Andrea L Schneider, Carrie Peltz, Yixia Li, Amber Bahorik, Raquel Gardner, W. J Boscardin, Kristine Yaffe

Cognitive Outcome 1 Year After Mild Traumatic Brain Injury: Results From the TRACK-TBI Study.

Neurology

Christman Schneider AL, Huie JR, Boscardin WJ, Nelson L, Barber JK, Yaffe K, Diaz-Arrastia R, Ferguson AR, Kramer J, Jain S, Temkin N, Yuh E, Manley GT, Gardner RC, TRACK-TBI Investigators

Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation.

The Lancet. Neurology

Galimberti S, Graziano F, Maas AIR, Isernia G, Lecky F, Jain S, Sun X, Gardner RC, Taylor SR, Markowitz AJ, Manley GT, Valsecchi MG, Bellelli G, Citerio G, CENTER-TBI and TRACK-TBI participants and investigators

Trajectories of Insomnia in Adults After Traumatic Brain Injury.

JAMA network open

Wickwire EM, Albrecht JS, Capaldi VF, Jain SO, Gardner RC, Werner JK, Mukherjee P, McKeon AB, Smith MT, Giacino JT, Nelson LD, Williams SG, Collen J, Sun X, Schnyer DM, Markowitz AJ, Manley GT, Krystal AD, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators

The Effect of Sex and Wealth on Population Attributable Risk Factors for Dementia in South Africa.

Frontiers in neurology

Bobrow K, Hoang T, Barnes DE, Gardner RC, Allen IE, Yaffe K

FAIR Data Reuse in Traumatic Brain Injury: Exploring Inflammation and Age as Moderators of Recovery in the TRACK-TBI Pilot.

Frontiers in neurology

Huie JR, Chou A, Torres-Espin A, Nielson JL, Yuh EL, Gardner RC, Diaz-Arrastia R, Manley GT, Ferguson AR, TRACK-TBI Investigators

Depression in Older Adults 12 Months Following Traumatic Brain Injury: A TRACK-TBI Study.

Archives of physical medicine and rehabilitation

Passler JS, Sander A, Temkin NR, Barber J, Gardner RC, TRACK-TBI Investigators*

Traumatic Brain Injury and Risk of Neurodegenerative Disorder.

Biological psychiatry

Brett BL, Gardner RC, Godbout J, Dams-O'Connor K, Keene CD

Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults.

Brain imaging and behavior

Asken BM, Mantyh WG, La Joie R, Strom A, Casaletto KB, Staffaroni AM, Apple AC, Lindbergh CA, Iaccarino L, You M, Grant H, Fonseca C, Windon C, Younes K, Tanner J, Rabinovici GD, Kramer JH, Gardner RC

Novel insights into risk of dementia after traumatic brain injury: A systematic review, meta-analysis, and heterogeneity analysis.

Alzheimer's & Dementia

Raquel C. Gardner, Amber L Bahorik, Paul Mangal, Isabel Elaine Allen, Kristine Yaffe

Feasibility and Utility of a Flexible Outcome Assessment Battery for Use in Longitudinal Traumatic Brain Injury Research.

Archives of physical medicine and rehabilitation

Yelena Bodien, Mark Sherer, Sabrina Taylor, Sureyya Dikmen, John Yue, Murray Stein, John Corrigan, Harvey Levin, Nancy Temkin, Joan Machamer, Kim Boase, Mary Vassar, Michael McCrea, Thomas McAllister, John Whyte, Jason Barber, Raquel Gardner, joel Kramer, Lindsay Nelson, Geoff Manley, Joseph Giacino

Physical and Functional Impairment Among Older Adults With a History of Traumatic Brain Injury.

The Journal of head trauma rehabilitation

Kornblith ES, Langa KM, Yaffe K, Gardner RC

Blood biomarkers of traumatic brain injury and cognitive impairment in older veterans.

Neurology

Peltz CB, Kenney K, Gill J, Diaz-Arrastia R, Gardner RC, Yaffe K

Screening for Lifetime History of Traumatic Brain Injury Among Older American and Irish Adults at Risk for Dementia: Development and Validation of a Web-Based Survey.

Journal of Alzheimer's disease : JAD

Gardner RC, Rivera E, O'Grady M, Doherty C, Yaffe K, Corrigan JD, Bogner J, Kramer J, Wilson F

Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy.

NeuroImage. Clinical

Lesman-Segev OH, La Joie R, Stephens ML, Sonni I, Tsai R, Bourakova V, Visani AV, Edwards L, O'Neil JP, Baker SL, Gardner RC, Janabi M, Chaudhary K, Perry DC, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD

Linguistic and Cultural Acceptability of a Spanish Translation of the Ohio State University Traumatic Brain Injury Identification Method Among Community-Dwelling Spanish-Dominant Older Adults.

Archives of Rehabilitation Research and Clinical Translation

Hufstedler HC, Dorsman KA, Rivera EJ, Lanata SC, Bogner JA, Corrigan JD, Fuller SM, Borja XR, Wilson F, Gardner RC

AGENT ORANGE EXPOSURE AND DEMENTIA DIAGNOSIS IN VIETNAM VETERANS: A CHRONIC EFFECTS OF NEUROTRAUMA CONSORTIUM STUDY.

Alzheimer's & Dementia

Deborah E. Barnes, Yixia Li, Amy L. Byers, Raquel C. Gardner, Carrie Peltz, Kristine Yaffe

COGNITIVE DECLINE ONE YEAR AFTER MILD TRAUMATIC BRAIN INJURY: A TRACK-TBI STUDY.

Alzheimer's & Dementia

Raquel C. Gardner, Russell Huie, Adam Ferguson, Kristine Yaffe, Geoffrey T. Manley, TRACK-TBI Investigators

Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies.

Brain : a journal of neurology

Spina S, Brown JA, Deng J, Gardner RC, Nana AL, Hwang JL, Gaus SE, Huang EJ, Kramer JH, Rosen HJ, Kornak J, Neuhaus J, Miller BL, Grinberg LT, Boxer AL, Seeley WW

Age and sex-mediated differences in six-month outcomes after mild traumatic brain injury in young adults: a TRACK-TBI study.

Neurological research

Yue JK, Levin HS, Suen CG, Morrissey MR, Runyon SJ, Winkler EA, Puffer RC, Deng H, Robinson CK, Rick JW, Phelps RRL, Sharma S, Taylor SR, Vassar MJ, Cnossen MC, Lingsma HF, Gardner RC, Temkin NR, Barber J, Dikmen SS, Yuh EL, Mukherjee P, Stein MB, Cage TA, Valadka AB, Okonkwo DO, Manley GT

Pre-injury Comorbidities Are Associated With Functional Impairment and Post-concussive Symptoms at 3- and 6-Months After Mild Traumatic Brain Injury: A TRACK-TBI Study.

Frontiers in neurology

Yue JK, Cnossen MC, Winkler EA, Deng H, Phelps RRL, Coss NA, Sharma S, Robinson CK, Suen CG, Vassar MJ, Schnyer DM, Puccio AM, Gardner RC, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Lingsma HF, Manley GT

Traumatic brain injury in older adults: do we need a different approach?

Concussion (London, England)

Peters ME, Gardner RC

Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans.

JAMA neurology

Barnes DE, Byers AL, Gardner RC, Seal KH, Boscardin WJ, Yaffe K

EARLY COGNITIVE DECLINE WITHIN ONE YEAR AFTER TRAUMATIC BRAIN INJURY: A TRACK-TBI STUDY.

Alzheimer's & Dementia

Raquel C. Gardner, Lindsay D. Nelson, John K. Yue, Alex B. Valadka, Michael A. McCrea, Joseph T. Giacino, Geoffrey T. Manley, TRACK-TBI Investigators

THE ROLE OF TRAUMATIC BRAIN INJURY IN THE DEVELOPMENT OF DEMENTIA: VALIDATION OF A WEB-BASED SELF-ADMINISTERED TRAUMATIC BRAIN INJURY EXPOSURE SURVEY FOR USE IN COGNITIVE AGING RESEARCH.

Alzheimer's & Dementia

Raquel C. Gardner, Ernesto Rivera, Megan O'Grady, Colin Doherty, Kristine Yaffe, Joel H. Kramer, Fiona Wilson

Age-Related Differences in Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein and Tau for Identifying Acute Intracranial Trauma on Computed Tomography: A TRACK-TBI Study.

Journal of neurotrauma

Gardner RC, Rubenstein R, Wang KKW, Korley FK, Yue JK, Yuh EL, Mukherje P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT

Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: a TRACK-TBI Pilot Study.

Brain injury

Ngwenya LB, Gardner RC, Yue JK, Burke JF, Ferguson AR, Huang MC, Winkler EA, Pirracchio R, Satris GG, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT

Mild TBI and risk of Parkinson disease: A Chronic Effects of Neurotrauma Consortium Study.

Neurology

Gardner RC, Byers AL, Barnes DE, Li Y, Boscardin J, Yaffe K

Geriatric Traumatic Brain Injury: Epidemiology, Outcomes, Knowledge Gaps, and Future Directions.

Journal of neurotrauma

Gardner RC, Dams-O'Connor K, Morrissey MR, Manley GT

Preinjury employment status as a risk factor for symptomatology and disability in mild traumatic brain injury: A TRACK-TBI analysis.

NeuroRehabilitation

Yue JK, Rick JW, Morrissey MR, Taylor SR, Deng H, Suen CG, Vassar MJ, Cnossen MC, Lingsma HF, Yuh EL, Mukherjee P, Gardner RC, Valadka AB, Okonkwo DO, Cage TA, Manley GT

Remote Traumatic Brain Injury Is Associated with Motor Dysfunction in Older Military Veterans.

The journals of gerontology. Series A, Biological sciences and medical sciences

Gardner RC, Peltz CB, Kenney K, Covinsky KE, Diaz-Arrastia R, Yaffe K

TRAUMATIC BRAIN INJURY (TBI) SEVERITY AND AGE OF DEMENTIA DIAGNOSIS AMONG VETERANS.

Alzheimer's & Dementia

Deborah E. Barnes, Raquel C. Gardner, Amy Byers, Karen Seal, W John Boscardin, Kristine Yaffe, Chronic Effects of Neurotrauma Consortium Study Group

The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a Public-Private Regulatory Collaboration To Accelerate Diagnosis and Treatment of Traumatic Brain Injury.

Journal of neurotrauma

Manley GT, Mac Donald CL, Markowitz AJ, Stephenson D, Robbins A, Gardner RC, Winkler E, Bodien YG, Taylor SR, Yue JK, Kannan L, Kumar A, McCrea MA, Wang KK

Chronic traumatic encephalopathy.

The Behavioral Neurology of Dementia

Raquel C. Gardner, David C. Perry

Neurobehavioral Characteristics of Older Veterans With Remote Traumatic Brain Injury.

The Journal of head trauma rehabilitation

Peltz CB, Gardner RC, Kenney K, Diaz-Arrastia R, Kramer JH, Yaffe K

Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia.

Brain : a journal of neurology

Vatsavayai SC, Yoon SJ, Gardner RC, Gendron TF, Vargas JN, Trujillo A, Pribadi M, Phillips JJ, Gaus SE, Hixson JD, Garcia PA, Rabinovici GD, Coppola G, Geschwind DH, Petrucelli L, Miller BL, Seeley WW

COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.

Neurogenetics

Winkler EA, Yue JK, McAllister TW, Temkin NR, Oh SS, Burchard EG, Hu D, Ferguson AR, Lingsma HF, Burke JF, Sorani MD, Rosand J, Yuh EL, Barber J, Tarapore PE, Gardner RC, Sharma S, Satris GG, Eng C, Puccio AM, Wang KK, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT

Evaluating and treating neurobehavioral symptoms in professional American football players: Lessons from a case series.

Neurology. Clinical practice

Gardner RC, Possin KL, Hess CP, Huang EJ, Grinberg LT, Nolan AL, Cohn-Sheehy BI, Ghosh PM, Lanata S, Merrilees J, Kramer JH, Berger MS, Miller BL, Yaffe K, Rabinovici GD

Cavum Septum Pellucidum in Retired American Pro-Football Players.

Journal of neurotrauma

Gardner RC, Hess CP, Brus-Ramer M, Possin KL, Cohn-Sheehy BI, Kramer JH, Berger MS, Yaffe K, Miller B, Rabinovici GD

Clinical profile of older veterans with remote tbi.

Alzheimer's & Dementia

Kristine Yaffe, Carrie Peltz, Raquel C. Gardner, Kimbra Kenney, Joel Kramer, Ramon Diaz-Arrastia

Traumatic brain injury in later life increases risk for Parkinson disease.

Annals of neurology

Gardner RC, Burke JF, Nettiksimmons J, Goldman S, Tanner CM, Yaffe K

Epidemiology of mild traumatic brain injury and neurodegenerative disease.

Molecular and cellular neurosciences

Gardner RC, Yaffe K

Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity.

JAMA neurology

Gardner RC, Burke JF, Nettiksimmons J, Kaup A, Barnes DE, Yaffe K

TRAUMATIC BRAIN INJURY AND DEMENTIA RISK: AGE AND SEVERITY MATTER.

Alzheimer's & Dementia

Raquel C. Gardner, Allison Kaup, Deborah E. Barnes, James Burke, Jasmine Nettiksimmons, Kristine Yaffe

Dementia in the oldest old: a multi-factorial and growing public health issue.

Alzheimer's research & therapy

Gardner RC, Valcour V, Yaffe K

Intrinsic connectivity network disruption in progressive supranuclear palsy.

Annals of neurology

Gardner RC, Boxer AL, Trujillo A, Mirsky JB, Guo CC, Gennatas ED, Heuer HW, Fine E, Zhou J, Kramer JH, Miller BL, Seeley WW

Reply.

Annals of neurology

Raquel C. Gardner, Jeremy D. Schmahmann

Development of a brief ataxia rating scale (BARS) based on a modified form of the ICARS.

Movement disorders : official journal of the Movement Disorder Society

Schmahmann JD, Gardner R, MacMore J, Vangel MG

Transient exacerbation of ataxia with smoking: a prevalence survey.

Movement disorders : official journal of the Movement Disorder Society

Gardner RC, Alcalay RN, Schmahmann JD

Ataxia and cerebellar atrophy--a novel manifestation of neuro-Behçet disease?

Movement disorders : official journal of the Movement Disorder Society

Gardner RC, Schmahmann JD