Risk and Resilience Factors for Cognitive Aging | Kristine Yaffe Group

Risk and Resilience Factors for Cognitive Aging

Our team has been at the forefront of identifying modifiable risk and resilience factors for cognitive and brain health. Team members have led some of the earliest investigations on the role of cardiovascular and metabolic risk factors, lifestyle behaviors, sleep disturbances, and other psychiatric and medical comorbidities.

Selected Publications

Jiang X, Bahorik AL, Dintica CS, Yaffe K. Cardiovascular-kidney-metabolic syndrome and incidence of dementia among older adults.external site (opens in a new window) J Prev Alzheimers Dis. 2025 May;12(5):100112. doi: 10.1016/j.tjpad.2025.100112. Epub 2025 Mar 4. PMID: 40044514; PMCID: PMC12184011.
Cavaillès, C., Yaffe, K., Blackwell, T., Buysse, D., Stone, K., & Leng, Y. (2023). Multidimensional Sleep Health and Long-Term Cognitive Decline in Community-Dwelling Older Men. external site (opens in a new window)Journal of Alzheimer's disease : JAD, 96(1), 65–71.
Brenowitz WD, Robbins NM, Strotmeyer ES, Yaffe K. Associations of Lower Extremity Peripheral Nerve Impairment and Risk of Dementia in Black and White Older Adults.external site (opens in a new window) Neurology. 2022 May 3;98(18):e1837-e1845.
Whitaker KM, Zhang D, Pettee Gabriel K, Ahrens M, Sternfeld B, Sidney S, Jacobs DR Jr, Palta P, Yaffe K. Longitudinal Associations of Midlife Accelerometer Determined Sedentary Behavior and Physical Activity With Cognitive Function: The CARDIA Study.external site (opens in a new window) J Am Heart Assoc. 2021 Feb 2;10(3):e018350.
Leng Y, Ackley SF, Glymour MM, Yaffe K, Brenowitz WD. Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Eldersexternal site (opens in a new window). Ann Neurol. 2021 Jan;89(1):177-181.
Rouch L, Vidal JS, Hoang T, Cestac P, Hanon O, Yaffe K. Systolic blood pressure postural changes variability is associated with greater dementia risk.external site (opens in a new window) Neurology. 2020 Oct 6;95(14):e1932-e1940.
McEvoy CT, Hoang T, Sidney S, Steffen LM, Jacobs DR Jr, Shikany JM, Wilkins JT, Yaffe K. Dietary patterns during adulthood and cognitive performance in midlife: The CARDIA study.external site (opens in a new window) Neurology. 2019 Apr 2;92(14):e1589-e1599.
Kaup AR, Byers AL, Falvey C, Simonsick EM, Satterfield S, Ayonayon HN, Smagula SF, Rubin SM, Yaffe K. Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia.external site (opens in a new window) JAMA Psychiatry. 2016 May 1;73(5):525-31.